The chimpanzee genome
نویسندگان
چکیده
منابع مشابه
Sequencing the Chimpanzee Genome
Sequence of the chimpanzee (Pan troglodytes) genome should be a high priority. The chimpanzee genome sequence will have a major impact on our understanding of human disease, human evolution, and human population genetics. We propose that the first phase of a project to obtain chimpanzee sequence consist of 3-4X whole-genome shotgun coverage, with the sequence obtained from multiple individuals ...
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Endogenous retroviruses (ERVs), eukaryotic transposable elements, exist as proviruses in vertebrates including primates and contribute to genomic changes during the evolution of their host genomes. Many studies about ERVs have focused on the elements residing in the human genome but only a few studies have focused on the elements which exist in non-human primate genomes. In this study, we ident...
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Evidence for the great similarity between chimpanzees and humans was recently reinforced with the publication of a rough draft of the chimpanzee genome. The sequence is in >361,000 pieces with a median length of 15,700 nucleotides. The sequence differs from the human genome by 35 million nucleotide mismatches (1.23%) and 10 million alignment gaps (~3-4%). Rather than attempting to explain this ...
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MicroRNAs are important negative regulators of gene expression in higher eukaryotes. The miRNA repertoire of the closest human animal relative, the chimpanzee (Pan troglodytes), is largely unknown. In this study, we focused on computational search of novel miRNA homologs in chimpanzee. We have searched and analyzed the chimp homologs of the human pre-miRNA and mature miRNA sequences. Based on a...
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With more than 1.2 million copies, Alu elements are one of the most important sources of structural variation in primate genomes. Here, we compare the chimpanzee and human genomes to determine the extent of Alu recombination-mediated deletion (ARMD) in the chimpanzee genome since the divergence of the chimpanzee and human lineages ( approximately 6 million y ago). Combining computational data a...
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ژورنال
عنوان ژورنال: Nature
سال: 2005
ISSN: 0028-0836,1476-4687
DOI: 10.1038/436047a